Physical Characterization

Particle Sciences is the leading particulate and device based drug product physical characterization company. With growing frequency, regulators are requiring tight control over physical parameters such as particle or droplet size, viscoelastic properties and the correlation of these parameters to efficacy. Particle Sciences is uniquely positioned to meet this challenge. Our facility is very well equipped and our staff has been at the cutting edge of regulated fine-particle and nanoparticle characterization for decades.

The facility operates under cGLPs/cGMP's, is FDA registered and DEA licensed for all schedules of controlled substances.

In addition to our advanced in-house physical characterization and analytic capabilities, our scientists can help you qualify suppliers, identify critical parameters for excipients and active substances, and develop and validate characterization methods, reducing variations in raw materials that can affect performance. Our facilities include:

  • Particle size via dynamic light scattering (DLS)
  • Particle size via laser diffraction
  • Particle size via X-ray disc centrifuge
  • Particle charge (zeta potential) by electrophoretic light scattering
  • Particle charge (zeta potential) by phase analysis light scattering
  • Rotational rheometry
  • Squeeze flow rheometry
  • Tensile and tack testing
  • Dynamic contact angle
  • Surface tension
  • Turbidity
  • Osmolality
  • Differential scanning calorimetry
  • Thermogravimetric analysis
  • Contact angle/surface energy measuring system
  • Turbiscan sedimentation-stability analyzer
  • HPLC with ultraviolet, photo diode array, refractive index, evaporative light scattering detectors
  • UV/VIS spectrometer
  • ICH temp/humidity stability chambers
  • ICH photostability chambers
  • LC/MS ion trap
  • LC/MS triple quad
  • FTIR
  • Microscopic image analysis
  • Fluorophotometer
  • Karl Fischer titration (Coulometric and volumetric)
  • Total organic carbon analyzer
  • Horiba Raman/particle characterization system