The ability to minimize inflammation plays a critical role in implantable system development.
Dexamethasone-Silicone can accelerate your product development cycle and help ensure your success.
All implantable systems trigger a foreign body response—an inflammatory cascade that results in fibrous encapsulation of any foreign object. While some implantable devices can tolerate the foreign body response, many next generation bio-sensors, controlled drug delivery devices, and tissue scaffolds require efficient interaction with surrounding tissue. Fibrous encapsulation can have detrimental effects on these devices, including:
Particle Sciences is addressing the growing need for implantable materials with our Dexamethasone-Silicone product offering. By combining a trusted, biocompatible polymer (silicone) with a safe, effective anti-inflammatory agent (dexamethasone), we have designed a ready-made material that is ideal for prototyping and product development efforts. As dexamethasone elutes from the silicone, it minimizes inflammation and limits the effect of the foreign body response on product performance. Dexamethasone-Silicone simplifies the product development process, helping you commercialize your implantable system faster.
Particle Sciences offers both Liquid Silicone Rubber (LSR) and High Consistency Rubber (HCR) containing 5% dexamethasone off-the-shelf. These materials are suitable for any implantable device developer who wants to quickly and easily evaluate dexamethasone in their application. If you require a different durometer of silicone or want a different loading of dexamethasone, we also offer custom orders. We can source your desired silicone, blend it with dexamethasone, and provide material to support your product development and prototyping efforts.
The base ingredients of Dexamethasone-Silicone are widely-used in both medical device and pharmaceutical drug products.
Particle Sciences’ ability to customize Dexamethasone-Silicone to your specific needs make it a highly versatile material. Potential applications for Dexamethasone-Silicone include:
Particle Sciences has decades of experience developing and manufacturing drug-device combination products. Our in-house capabilities include extensive modeling, physical characterization, injection molding, high shear mixing, extrusion, co-extrusion, and compounding. We have formulated a range of drugs, including highly potent compounds and controlled substances, and Particle Sciences has established preferred relationships with the world's leading polymer suppliers and CMOs, which ensures a seamless path to commercialization for our clients
Our Dexamethasone-Silicone product offering is a quick, inexpensive way to evaluate material for your next implantable device, but if Dexamethasone-Silicone is not the right material for your application, we can always help you find an appropriate solution. Regardless of which polymer and drug you are working with, if you choose to move forward with your project, we have the personnel, facilities, and equipment to produce clinical and commercial scale material to support your project. If you are developing an implantable system or are interested in learning more about implantables, contact us today and let us take your product from concept to commercial.