Particle Sciences has been at the forefront of drug delivery related fine-particle and nanotechnology formulation since the early 1990s. We provide a wide range of particulate fabrication and drug product preparation services. Our efforts have resulted in commercial products including nanoparticles scaled to as much as half a million kilos per year. Whether it's Particle Sciences' proprietary technology or conventional systems, our staff knows how to apply these tools to meet your needs.
The incorporation of an API into a particle can take many forms. Possibilities range from an emulsion droplet to any number of encapsulation systems to a Lyocell® to a nanoparticle of the API itself. In addition to the API, the particle can be decorated with various moieties including targeting agents as is done with our Surface Arrayed Therapeutics ™ (SATx™) technology. These various formats cover a range of sizes from tens of microns down to several nanometers, each providing their own utility with respect to any given API. Reasons for using a nanoparticle or larger particulate can include:
Having a full range of technologies and the needed equipment provides us with options assuring that the best solution for our client is achieved. Our particle & nanoparticle engineering expertise includes, among others, micronized particulates (eg jet-milling), spray drying, emulsions, suspensions, liposomes, LyoCells®, solid lipid nanoparticles, polymer nanoparticles, PEGPLUS™, coacervates and polyelectrolyte complexes, and micro/nano capsules.
Our micro/nanoparticle fabrication labs are supported by in-house cGMP/cGLP analytic facilities and ICH stability testing programs. We can seamlessly bring your product into the clinic, producing clinical trial materials and commercial supplies. We have worked with small molecules, oligonucleotides, peptides, proteins and carbohydrates. We are FDA registered and DEA licensed for all scheduled substances.
Particle Sciences provides SATx services to help those clients needing to associate large and small molecules with each other. Traditionally, antibody drug conjugates (ADC) have been the go-to approach. With its SATx services, Particle Sciences now offers a simpler, more versatile approach. By incorporating your API into a nanoparticle and then non-covalently attaching the biologic to the surface of the particle, we create a complex that is both robust and cost efficient. With the SATx system, we can tailor the ratio of API to biologic, provide targeted delivery and do so all without any covalent modifications to the API or biologic. Because of this, both development and regulatory pathways are shortened. The technology is patented and unique to Particle Sciences. Please contact us to see how the SATx system can help you.
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