Micro & Nano Technology

Particle Sciences has been at the forefront of drug delivery related fine-particle and nanotechnology formulation since the early 1990s. We provide a wide range of particulate fabrication and drug product preparation services. Our efforts have resulted in commercial products including nanoparticles scaled to as much as half a million kilos per year. Whether it's Particle Sciences' proprietary technology or conventional systems, our staff knows how to apply these tools to meet your needs.

The incorporation of an API into a particle can take many forms. Possibilities range from an emulsion droplet to any number of encapsulation systems to a Lyocell® to a nanoparticle of the API itself. These various formats cover a range of sizes from tens of microns down to several nanometers, each providing their own utility with respect to any given API. Reasons for using a nanoparticle or larger particulate can include:

  • Incorporation of difficult to solubilize APIs
  • Controlling bioavailability
  • Controlling drug/excipient interaction
  • Improving API stability
  • Targeted delivery
  • Controlling uniformity
  • Taste masking
  • Altering pharmacokinetic and toxicological profiles
  • Intellectual property
  • Lifecycle management

Having a full range of technologies and the needed equipment provides us with options assuring that the best solution for our client is achieved. Our particle & nanoparticle engineering expertise includes, among others, micronized particulates (eg jet-milling), spray drying, emulsions, suspensions, liposomes, LyoCells®, solid lipid nanoparticles, polymer nanoparticles, PEGPLUS™, coacervates and polyelectrolyte complexes, and micro/nano capsules.

Our micro/nanoparticle fabrication labs are supported by in-house cGMP/cGLP analytic facilities and ICH stability testing programs. We can seamlessly bring your product into the clinic, producing clinical trial materials and commercial supplies. We have worked with small molecules, oligonucleotides, peptides, proteins and carbohydrates. We are FDA registered and DEA licensed for all scheduled substances.

Partial Equipment List

  • Microscopic image analysis
  • Gel electrophoresis
  • Particle size via dynamic light scattering (DLS)
  • Particle size via laser diffraction
  • Particle size via X-Ray disc centrifuge
  • Particle charge (zeta potential) by electrophoretic light scattering
  • Particle charge (zeta potential) by phase analysis light scattering
  • Rotational rheometry
  • Squeeze flow rheometry
  • Modulus and tensile strength testing
  • Tack, shear and peel adhesive testing
  • Dynamic contact angle
  • Surface tension
  • Turbidity
  • Osmolality
  • Class 10,000 (ISO 7) through 100 (ISO 5) Cleanroom
  • Sterile laminar flow hood
  • Silverson L4RT-A laboratory homogenizer with in-line capability
  • Ad-mix Benchmix OPLB-300 Rotosolver
  • Three Ultrasonic 500W dispersers/homogenizers with in-line capability
  • Netzsch Labstar LS1 media mill
  • Two Buchi B-290 Mini-spray dryers with organic solvent capability
  • Multiple Sturtevant Qualification Micronizers with sanitary collector capability
  • Roller mills
  • Differential scanning calorimetry
  • Turbiscan sedimentation-stability analyzer
  • HPLC with UV-VIS, photo diode array, Fluorescence Evaporative Light Scattering detectors
  • UV/VIS spectrophotometer
  • In vitro elution kinetics
  • In vitro dissolution kinetics
  • ICH photo/temp/humidity stability chambers
  • LC/MS ion trap
  • LC/MS triple quad
  • FTIR
  • Fluorophotometer
  • ELISA
  • Karl Fischer titration (Coulometric and volumetric)
  • Total organic carbon analyzer
  • Buchi Encapsulator B-390
  • Netzsch DeltaVita® 15-300
  • Millrock Max Series with VHP sterilization
  • Gaulin 15MR laboratory homogenizer
  • Lyophilizers
  • Watersep bench-scale tangential flow filtration unit
  • Multiple Stability Chambers
  • Autoclave
  • Fill Integrity Tester
  • M-110EH-30 Basic BioPharma Microfluidizer
  • Semi-automated film and coating