Minimize time and risk between discovery and the clinic
Particle Sciences offers a broad array of integrated services and solutions to streamline development and minimize risk.

Physical Characterization
Consistency and quality are critical to development. The physical state of an API and the formulation will largely dictate, among other things, stability, bioavailability and ultimately, performance. As API's move further away from small, easily soluble molecules, these issues have increasing importance.

With growing frequency, regulators are requiring tight control over physical parameters such as particle or droplet size, viscoelastic properties and the quantification of the relationship of such parameters to drug release. Particle Sciences is uniquely positioned to meet this challenge. Our facility is very well equipped and our staff have been at the cutting edge of fine-particle and nanoparticle characterization for decades and we bring this expertise to the pharmaceutical industry.

In addition to our advanced in-house physical characterization and analytic capabilities, our scientists can help you qualify suppliers, identify critical parameters for excipients and active substances, and develop and validate characterization methods, reducing variations in raw materials that can affect performance. Our facilities include:

  • Particle Size via Dynamic Light Scattering (DLS)
  • Particle Size via Laser Diffraction
  • Particle Size via X-Ray Disc Centrifuge
  • Particle Charge (zeta potential) by Electrophoretic Light Scattering
  • Particle Charge (zeta potential) by Phase Analysis Light Scattering
  • Rotational Rheometry
  • Squeeze Flow Rheometry
  • Tensile and Tack Testing
  • Dynamic Contact Angle
  • Surface Tension
  • Turbidity
  • Osmolality
  • Differential scanning calorimetry
  • Contact angle/surface energy measuring system
  • Turbiscan sedimentation-stability analyzer
  • HPLC with Ultraviolet, Photo Diode Array, Refractive Index Evaporative Light Scattering” Detectors
  • UV/VIS Spectrometer
  • ICH Temp/Humidity Stability Chambers
  • ICH Photostability Chambers
  • LC/MS Ion Trap
  • LC/MS Triple Quad
  • UV/Vis
  • FTIR
  • Differential scanning calorimetry
  • Microscopic image analysis
  • Fluorophotometer
  • Percutaneous absorption (IVRT)
  • ICH Temp/Humidity Stability Chambers
  • ICH Photostability Chambers
  • Karl Fischer Titration
  • Total Organic Carbon Analyzer
  • Malvern Zetasizer APS Dynamic Light Scattering System
  • Horiba Raman/Particle Characterization System
Download the Particle Sciences brochure »
Learn More about Particle Sciences»
For more information about how Particle Sciences can seamlessly take your drug from discovery to clinic, please contact us today.