Minimize time and risk between discovery and the clinic
Particle Sciences offers a broad array of integrated services and solutions to streamline development and minimize risk.

Micro / Nano Technology
The incorporation of an API into a particle can take many forms. Possibilities range from an emulsion droplet to any number of encapsulation systems to a nanocrystal of the API itself. These various formats cover a range of sizes from tens of microns down to several nanometers, each providing their own utility with respect to any given API.

At Particle Sciences, our goal is to find the most practical solution for your application. Particle Sciences has been at the forefront of fine-particle and nanotechnology since the early 1990s. Our efforts have resulted in commercial products scaled to as much as half a million kilos each year. Whether it's Particle Sciences proprietary technology or conventional systems, our staff knows how to apply these tools to meet your needs.

Particle Sciences is equipped with a wide range of production equipment and characterization instrumentation. This provides our clients with a broad choice of technologies assuring that the best solution is achieved. Our expertise in fine-particle and nanotechnology includes micronized particulates, spray drying, emulsions, suspensions and encapsulated systems. Our skills are applicable to even the most difficult to solubilize APIs.

Using fine-particle and nanotechnology approaches can help address a number of issues in drug development. They include:

  • Incorporation of difficult to solubilize APIs
  • Controlling bioavailability
  • Controlling drug/excipent interaction
  • Improving API stability
  • Targeted delivery
  • Controlling uniformity
Particle Sciences' staff have designed and scaled many fine-particle and nanotechnology systems. By engaging Particle Sciences you are benefiting from this pool of experience.

Our micro/nano development labs are extremely well equipped and are supported by in-house GMP/GLP analytic facilities and ICH stability programs. We have worked with small molecules, oligos, peptides, proteins and sugars. We are registered with the DEA and can work with controlled substances. In conjunction with our clients, we design the optimum program to achieve the desired output.

Partial Equipment List

  • Microscopic image analysis
  • Gel Electrophoresis Particle Size via Dynamic Light Scattering (DLS)
  • Particle Size via Laser Diffraction
  • Particle Size via X-Ray Disc Centrifuge
  • Particle Charge (zeta potential) by Electrophoretic Light Scattering
  • Particle Charge (zeta potential) by Phase Analysis Light Scattering
  • Rotational Rheometry
  • Squeeze Flow Rheometry
  • Tensile and Tack Testing
  • Dynamic Contact Angle
  • Surface Tension
  • Turbidity
  • Osmolality
  • Differential scanning calorimetry
  • Contact angle/surface energy measuring system
  • Turbiscan sedimentation-stability analyzer
  • HPLC with Ultraviolet, Photo Diode Array, Refractive Index Detectors
  • UV/VIS Spectrometer
  • In-vitro release studies
  • ICH photo/Temp/Humidity Stability Chambers
  • LC/MS Ion Trap
  • LC/MS Triple Quad
  • FTIR
  • DSC
  • Fluorophotometer
  • ELISA
  • Karl Fischer Titration
  • Organic Carbon Analyzer
When ready, Particle Sciences can scale nanoparticle production to clinical and production levels. We routinely produce close to 50,000 kilograms of nanoparticle dispersions per year for our clients. With processing equipment ranging from high shear emulsifiers to spray dryers to ball mills, Particle Sciences is well equipped to rapidly advance your project.
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For more information about how Particle Sciences can seamlessly take your drug from discovery to clinic, please contact us today.